CitriTherm™ Clinical Studies
Sinetrol® helps stimulate lipolysis* through the inhibition of phosphodiesterase 4 (PDE-4), which leads to the breakdown of triglycerides stored in fat cells (adipocytes) and the release of free fatty acids (FFAs) and glycerol.
In addition, polyphenols present in Sinetrol® have been reported to help induce the expression of fatty acid oxidation genes, which coax the metabolism toward the use of FFAs to produce additional energy.
To determine the weight-loss benefits of Sinetrol®, a prospective placebo-controlled clinical study was conducted in 20 subjects.
After 3 months, the Sinetrol group lost an average of 5.6kg and 22% of body fat compared to the placebo group.
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Further clincal studies on Sinetrol
To further investigate the efficacy and safety of Sinetrol® for body weight management and improvement of metabolic disturbances with reduction in oxidative stress, a second clinical study was performed using Sinetrol® Xpur. This study was published in 2013.
- Randomized, double-blind, placebo-controlled.
- 95 overweight subjects (BMI=26–29.9) in 2 groups: Sinetrol® Xpur (n=47) with 2x450mg/day or a placebo (n=48).
- 12-week supplementation.
- Normal diet and 30min/week of physical activity.
Sinetrol® helps in supporting the body by:
Proven fat loss: abdominal body fat decreased by 9.73% (p<0.0001) in the Sinetrol® Xpur group (6.55% more than with placebo). Waist and hip circumferences were respectively reduced by 5.15cm and 5.17cm (each, p<0.0001).
Encourages lipolysis: FFA release in the plasma showed significantly higher levels (p<0.0001) in the Sinetrol® Xpur group (more than a 300% increase) compared to the placebo group, in which the increase was only 30%.